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New insights from animal models of colon cancer: inflammation control as a new facet on the tumor suppressor APC

Escrito por Carla Brito Lopes

Abstract: Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide. As with other cancers, CRC is a genetic disease, however, several risk factors including diet and chronic colitis predispose to the disease. Mutations in the tumor suppressor adenomatous polyposis coli (APC) initiate most cases of CRC. Recent data from mouse models suggest that APCmutations and colitis are not completely independent factors in colorectal carcinogenesis. Here, we review the evidence supporting an interaction between APC mutations and chronic colitis. We will also discuss possible pathophysiologic mechanisms behind this interaction.

Keywords: rodent model, colon cancer, adenomatous polyposis coli, APC, tumor suppressor, inflammatory bowel disease


 

Article first published: 30 January 2015
doi: http://dx.doi.org/10.2147/GICTT.S51386
URL: Download Article [PDF]

Citation: [Zeineldin M, Neufeld KL. New insights from animal models of colon cancer: inflammation control as a new facet on the tumor suppressor APC gem. Gastrointestinal Cancer: Targets and Therapy 2015:5 39–52]

Copyright: © 2015 Zeineldin and Neufeld. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/.

Sobre o autor

Carla Brito Lopes

Carla nasceu a 14 de Fevereiro de 1977 em Viana do Castelo. Completou o bacharelato em Anatomia Patológica, Citológica e Tanatológica na ESTES-Porto em 1998 e licenciou-se em 2001 pela Escola Superior de Tecnologia da Saúde em Lisboa. Concluiu a certificação em Laboratory Management pela ASCP (American Association of Clinical Pathology) em Setembro de 2016.
Actualmente encontra-se a frequentar mestrado em Genética Molecular e Biomedicina na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa.