Genética

MicroRNAs as Essential Components of Non-Coding Genome are Emerging Key Players of Oncogenesis

Escrito por Carla Brito Lopes

MicroRNAs (miRNAs) were originally identified in 1993, when a non-coding small RNA gene, lin-4, has been discovered in a genetic screen utilized to find out genes controlling developmental timing of the nematode, Caenorhabditis elegans larvae.

Findings about lin-4 and other newly discovered small non-coding RNAs having the capacity to alter gene expression post-transcriptionally in a variety of species including mammalians, put forward miRNAs, which, are endogenously synthesized, approximately 22 nucleotide-long, single stranded and non-coding RNAs, as indispensable components of noncoding genome.

Since their discovery, hundreds of miRNAs have been shown to play essential roles through modulating expression of their validated targets in several biological events both in physiological and pathological conditionsand they are estimated to regulate the expression of at least 60% of human genes.

 

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Article first published: October 07, 2013
DOI: 10.4172/2168-9547.1000e112
Pode descarregar o artigo completo aqui:
http://omicsgroup.org/journals/micrornas-as-essential-components-of-noncoding-genome-are-emerging-key-players-of-oncogenesis-2168-9547.1000e112.pdf

Citation: [Ozen M, Karatas OF (2013) MicroRNAs, as Essential
Components of Non-Coding Genome, are Emerging Key Players of
Oncogenesis. Mol Biol 2:e112.]

Copyright: © 2013 Ozen M, et al. This is an open-access article
distributed under the terms of the Creative Commons Attribution
License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original author and source
are credited.

Sobre o autor

Carla Brito Lopes

Carla nasceu a 14 de Fevereiro de 1977 em Viana do Castelo. Completou o bacharelato em Anatomia Patológica, Citológica e Tanatológica na ESTES-Porto em 1998 e licenciou-se em 2001 pela Escola Superior de Tecnologia da Saúde em Lisboa. Concluiu a certificação em Laboratory Management pela ASCP (American Association of Clinical Pathology) em Setembro de 2016.
Actualmente encontra-se a frequentar mestrado em Genética Molecular e Biomedicina na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa.